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New Multi-target Antagonists of α1A-, α1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure.
Nascimento-Viana JB, Carvalho AR, Nasciutti LE, Alcántara-Hernández R, Chagas-Silva F, Souza PA, Romeiro LA, García-Sáinz JA, Noël F, Silva CL. Nascimento-Viana JB, et al. Among authors: romeiro la. J Pharmacol Exp Ther. 2016 Jan;356(1):212-22. doi: 10.1124/jpet.115.227066. Epub 2015 Oct 22. J Pharmacol Exp Ther. 2016. PMID: 26493747
Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth.
Chagas-Silva F, Nascimento-Viana JB, Romeiro LA, Barberato LC, Noël F, Silva CL. Chagas-Silva F, et al. Among authors: romeiro la. Naunyn Schmiedebergs Arch Pharmacol. 2014 Mar;387(3):225-34. doi: 10.1007/s00210-013-0935-3. Epub 2013 Nov 10. Naunyn Schmiedebergs Arch Pharmacol. 2014. PMID: 24213881
The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment.
Costa FB, Cortez AP, de Ávila RI, de Carvalho FS, Andrade WM, da Cruz AF, Reis KB, Menegatti R, Lião LM, Romeiro LAS, Noël F, Fraga CAM, Barreiro EJ, Sanz G, Rodrigues MF, Vaz BG, Valadares MC. Costa FB, et al. Among authors: romeiro las. Biomed Pharmacother. 2018 Jun;102:481-493. doi: 10.1016/j.biopha.2018.02.120. Epub 2018 Apr 5. Biomed Pharmacother. 2018. PMID: 29579709